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The Amazing Science of CytoDetox.

The scientific breakthrough of CytoDetox is the result of years of research, testing, and collaboration among the top biochemists and doctors in the field. In 2001, a unique crystal called zeolite clinoptilolite was grown by NASA in space for its extraordinary trapping and exchanging properties. Today, this molecule is the ingredient that gives CytoDetox the ability to safely and naturally support the removal of toxins from the human body at the cellular level.

Why It Works
CytoDetox has created a groundbreaking change in supporting the body’s natural cell detoxification systems.

Many people have introduced liquid zeolites, powdered clinoptilolite zeolite, and other zeolite products and structures.

The problem is these liquid zeolites only contained particles which may be supportive to the body, with one caveat.

Based upon the size of the particle, they stay in the gut and cannot pass cellular membranes. As a result, none of these other products prove to be effective. And most other natural binders available cannot keep a strong hold on heavy metals. As a result, metals are not completely eliminated, and therefore can re-circulate back into the body.

The clinoptilolite zeolite found in CytoDetox® can fully bind and hold heavy metals and other toxins tightly, therefore, re-distribution in the body is no longer a valid concern [1].
The Origin Story of CytoDetox You Need to Know
CytoDetox differentiates itself from all other zeolites and cell detoxification support products.

CytoDetox is derived from a special type (1 of 40) of zeolites called clinoptilolite [2,3].

From a ‘birds-eye’ perspective, this natural mineral, clinoptilolite, formed millions of years ago from a chemical reaction between volcanic ash and saline water. It can take up to 50,000 years to complete this reaction [4]. Once complete, a unique three-dimensional cage like configuration is created, similar to a honeycomb, which has a natural negative charge. This natural structure acts like a sieve for toxins in the environment [5,6,7].

The clinoptilolite crystal structure is built from Aluminum, Silica and Oxygen creating a very stable and resistant molecule that can attract, exchange, and retain heavy metals and other positively charged toxic molecules.

Commercially, the zeolite structure functions as an effective tool for cationic exchange and absorption of heavy metals such as Uranium, Lead, and Mercury. They have a long history of use in many water filtration systems available both commercially and publicly. In fact, for human use, the FDA considers zeolites to be GRAS (Generally Regarded As Safe) as a food additive [8].

The challenges with zeolite crystals is two-fold:
1. They naturally contain high levels of heavy metals making it difficult to use higher and more effective quantities in formulas.
2. They are large insoluble cage molecules that would not cross the intestinal barriers or membranes.

Heavy Metal Contamination Free Purified Clinoptilolite Zeolite
Natural clinoptilolite zeolite is difficult to use in human systems because, when not cleaned, it naturally contains high level of heavy metals and other contaminants, therefore it has to be diluted significantly before consumption. This limits its overall effectiveness, efficacy and work against supporting cell detoxification.

Using a patent pending process, the natural clinoptilolite zeolite in CytoDetox is stripped of the bound heavy metals, leaving cleaned and prepped cages ready for binding new heavy metals. This purified clinoptilolite zeolite can be used at higher concentrations making it much more effective. Because it has more cleaned cages, it is capable of binding to a higher capacity, heavy metals, and larger toxic molecules.
Molecule Clinoptilolite Fragment Found in CytoDetox
When zeolite is added to water and stirred, a suspension is created. But, as noted, most other zeolite suspensions cannot be absorbed, and have a limited bioavailability in the human gastrointestinal system.

Therefore, any zeolite products that were made before the technology existed to create CytoDetox® were either powdered zeolites or liquid suspensions of zeolites, and absorption was a concern.

CytoDetox contains water-soluble molecular clinoptilolite fragments, as well as some larger insoluble particles with cleaned cages. This is what differentiates it from other zeolite products. Simply, it was designed to support the whole body not just the gut.

In order to transform the zeolite structure or crystal into a water-soluble crystalline molecule, the zeolite structure needs to be broken down into the correct size and molecular weight.

During the process of creating the product, the challenge became breaking the crystal and creating molecular clinoptiloite fragments, while simultaneously making sure to preserve the cage-like structures necessary to maintain the ability to bind heavy metals and other toxins.

After thorough testing, the water soluble molecular clinoptilolite fragments found in solution are the correct size and molecular weight necessary to maintain cage like zeolite structure(s). The fingerprint of the molecular clinoptilolite fragments was confirmed by liquid chromatography and mass spectrometry (LC-MS) to range between 200 and 1000 daltons (more than 10 times the molecular weight that is able to cross a cells mitochondrial membrane).
Laboratory Testing and Safety
Every batch of CytoDetox is tested with a full microbiological testing, according to strict industry requirements. Moreover, the lab operates according to the FDA, cGMP or GLP (good laboratory practices). The testing methodology used is United States Pharmacopeia (USP)/Bacterilogical Analytical Manual (BAM) and Association of Analytical Chemists (AOAC) methodologies.

Our purified CytoDetox® test results for heavy metals, and microorganisms surpass all specifications even at higher clinical concentrations.

Also noteworthy: clinoptilolite zeolite particles contain sodium aluminosilicate, which means their chemical makeup is aluminum, silica and oxygen. This may create the thought that ‘free aluminum’ could enter the body. However, the lab process and analytical analysis suggests that when they broke the crystals, there were no detectable levels of free aluminum in the finished product.

What about our zeolite cages that contain aluminum in the structure?

The soluble molecular clinoptilolite fragments and insoluble clinoptilolite particles are not ‘free aluminum’, rather, these are inert parts of the zeolite structure. This structure is very difficult to break, even in a laboratory setting with strong and caustic chemicals.

Clinoptilolite zeolite can also withstand extremely high temperatures (>1000 ℉), and is not dissolved or broken down by gastric or stomach acids. Therefore, the molecular clinoptilolite fragments and particles can pass through the body completely intact.

As the clinoptilolite zeolite particles and water soluble fragments move through the body, they can easily and safely support the body’s natural ability to detoxify, when they are activated and cleansed of their existing metals.
Crossing Through Cellular Membranes
The real proof of a true cellular binder’s efficacy is whether it can successfully cross cellular membranes as well as the blood brain barrier. To have confidence in a binder, it needs to perform in specific tests that can confirm its ability to travel through cellular membranes unimpeded.

To support CytoDetox’s ability to cross cellular membranes, we must return to biology class, and review how a compound crosses cell membranes. Cell membranes are semi-permeable barriers and gatekeepers to the cell. This means that some molecules can diffuse across the lipid bilayer quickly, slowly, or not all all depending on several factors like charge and size.

Pharmaceutical companies developed the science of liposomes to help deliver drugs into the lymph, blood and targeted tissues through the cells lipid bilayer. We adopted this same science to create the first and only clinoptilolite zeolite liposomes.

Using CytoDetox’s® patent pending liposomal technology we can support the delivery of clinoptilolite molecules beyond cellular barriers.
Why Size Matters in Clinoptilolite Zeolite Structure(s)
CytoDetox contains clinoptilolite that range in molecular size (not weight) from approximately 1 to over 1000 nanometers. This produces various sizes and clusters of cage structures that have the ability to bind larger quantities of toxins in different body systems.

When it comes to cellular membranes, studies show molecular weight, not the measured size is what matters to the cells. The molecular weight (measured in daltons), is what defines a molecules ability to cross into cells and cellular membranes.

LC-MS testing confirmed that the molecular weight of the water soluble clinoptilolite fragments present in CytoDetox are in the range (200 and 1000 daltons) necessary to cross cellular membranes.

Also, insoluble (not water soluble) clinoptilolite particles that are too large to enter cellular membranes, where also added to CytoDetox’s liposomal solution.

These larger clinoptilolite particles were added to further support the body’s natural ability to detoxify other body systems, such as the blood, lymph and gut.
In addition, we have taken a proven delivery system called liposomal technology to support the transport of clinoptilolite zeolite molecules across cellular membranes.

The creation of clinoptilolite zeolite liposomes further supports the delivery of clinoptilolite molecules (varying molecular weights, sizes, and concentrations) into the lymphatic system, thus providing increased access to blood, cells and tissues.

Even smaller clinoptilolite zeolite molecules may encounter barriers like intestinal tight junctions or membranes, therefore, liposomes increase the efficacy and molecular concentration of every dose.

Liposomes fuse with membranes, and then can release contents into the cell. The liposomes present in CytoDetox are small and stable ranging in size from approximately 20 to 250 nanometers.

We measure the molecular clinoptilolite fragments to verify the dalton size required for inclusion into the liposomal matrix.

Increased Binding Mechanism and Capacity with Fulvates
To support the amazing discovery of molecular clinoptilolite fragments the inventors combined a natural organic acid called fulvates to the CytoDetox formula. In the natural environment, the combination of organic acids like fulvates with zeolites increased heavy metal uptake and binding capacity [10].

Fulvates contain over 33 types of organic acids, amino acids and trace minerals all of which can be beneficial to our cells. Similar to clinoptilolite fragments, fulvates are fragments derived from humates. Fulvates have increased solubility and lower molecular weight while retaining phenolic carboxylic acid groups. Therefore, fulvic acids can bind metals through a true chelation process. Also, research indicates that fulvates are a natural redox molecule with antioxidant capacity and may neutralize harmful free radical toxins in the body [11].

The processes in which fulvates are believed to eliminate toxins is complex. The redox potential provides the capacity to carry an electron charge that counteracts the detrimental effects of charged free radicals, or directly as a chelator fulvates use the negatively charged oxygens to trap positively charged minerals like heavy metals.

In sum, fulvates can serve multiple roles within the human body systems to support cell detoxification and cell function. As an electron donor and acceptor, fulvates can provide redox potential-a life force energy. As complex organic molecules fulvates deliver microbiome nourishment, trace minerals and other nutrients to the body [12].
Going Upstream to the Toxin Source
When looking at upstream toxins (such as heavy metals and environmental chemicals embedded in most of our organs, glands, cells and brain tissue), we know it is of utmost importance to deal with high toxicity in a timely and safe manner.

Unfortunately, you can’t just do a liver or kidney cleanse once a year and think that you are fully cleansed. It is impossible to single out an organ and limit cell detoxification to one part of the body. Even if we were able to select toxins from the liver one at a time, we could only remove an estimated 2% or 3% of the toxic load.

Toxins pass through the liver to be removed, but often end up deposited in fatty tissue and other body tissues, including the brain. What we can do is take CytoDetox to support the body’s natural ability to pass toxins through the liver, and usher them out of the system for complete cell detoxification support.

Note, CytoDetox does not limit itself to supporting removal of heavy metals such as mercury, lead, cadmium and arsenic. CytoDetox can fully support the body for a wide variety of positively charged toxic exposures.

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