AOR SAMe 400mg 60 tabs.

  SAMe and Depression It is as an anti-depressant that SAMe seems to have established itself in the collective mindset of the scientific community. The influence of the methylation cycle is so widespread that it affects factors of the central nervous system that are directly pertinent to depression. To begin with, methionine requires one-carbon groups to begin the methylation cycle. These one-carbon groups rely heavily on the B-complex vitamins for their amalgamation by methionine for the methylation cycle and the subsequent conversion to SAMe. The fact that inadequate concentrations of these vitamins are synonymous with depression have led researchers to theorize that supplemental SAMe enhances the metabolism of the B family of vitamins (especially folic acid), thus explaining the anti-depressant power within SAMe’s range of benefits. Another possible (and perhaps concurrent) explanation of SAMe’s anti-depressant properties is its effect on neurotransmitters in the brain, especially serotonin and dopamine. Serotonin is formed from tryptophan and has an important effect on learning, sleep, and the regulation of mood. The latter’s connection to depression is quite palpable, and SAMe is widely known to raise serotonin levels in the brain, providing another possibly accumulative avenue for the speed and effectiveness of its anti-depressant activity. Dopamine is another neurotransmitter that likely plays an even bigger role in the averting of depression than serotonin. Low concentrations of dopamine are not only affiliated with the conditions of depression (as are lower concentrations of serotonin) but they are also closely associated with Parkinson’s disease as well. SAMe’s effect on depression may also be linked to the hormone melatonin. Melatonin is derived from serotonin and plays an important role in sleep and by extension the aging process. Like the neurotransmitters serotonin and dopamine, low levels of melatonin are a frequently consistent observation in people suffering from depression. SAMe’s effectiveness as an anti-depressant has been demonstrated in many clinical trials.