A Metabolic Key SAMe is a key factor in several biological events, particularly in methylation cycles. These cycles are one of the most common metabolic functions and drive many essential processes in the body. SAMe’s importance in the methylation cycle gives it roles in supporting joint health, mobility, normal liver function and mood. Look on the Bright Side of Life Methylation cycles in the central nervous system affect factors that are directly related to depression. SAMe affects the metabolism of B vitamins and neurotransmitters such as serotonin and dopamine, which are important in averting depression. SAMe’s effects on depression are so powerful that it is a legally registered prescription drug in several European countries. Help for Bones and Liver Clinical trials have found SAMe to be effective in relieving symptoms and reducing functional impairment in osteoarthritis. SAMe promotes liver health by protecting the liver from various toxins, and it acts as an antioxidant and anti-inflammatory agent. These important benefits make SAMe a good choice for maintaining and enjoying good health.